The new mind-body science of depression / Vladimir Maletic, Charles Raison.

Includes bibliographical references and index.

Does major depression exist? or why the diagnostic rule book is (mostly) wrong -- Building a new phenomenology of depression where genes and the environment meet -- Environmental adversity, loss of evolutionary fitness and the development of MDD -- Genetics of MDD -- Depression and the brain-body dance : role of neuroendocrine and autonomic pathways -- The immune system : relationships with the stress system and role in the pathogenesis of major depression -- Neuroplastic, inflammatory and cellular changes in depression -- Functional and structural brain changes in depression -- Changes in neurotransmission and subcellular function in depression, or the secret of shogun's box -- Exploring the role of pathogen host defense in the evolution of depression and its risk genes -- The case of Mary -- The case of Anna -- The case of Thomas.