Computational systems bioinformatics : methods and biomedical applications / Xiaobo Zhou, Stephen T.C. Wong.

Includes bibliographical references and index.

Mathematical, statistical, and data mining principles -- Missing value estimation using KNN and Bayesian methods -- Normalization, scaling, and discretization -- Cross-platform comparison -- Discovering differential biomarkers -- Gene selection and classification -- Gene clustering -- Gene prediction.

Reverse engineering : gene regulatory network construction and its behavior -- Motif detection and transcription factor binding site (TFBS) identification -- Integrated microarray and gene sequence analysis -- Protein structure informatics -- Biomarker discovery from proteomics -- Bio-imaging informatics -- Conclusions.

"This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research."--Jacket.